английский => русский Медицина Медицина: Кардиология сердечная недостаточность

The use of 99m Tc bone-avid compounds for bone scintigraphy allows for noninvasive diagnosis of ATTR-CM. 99m Tc compounds include PYP, 3,3-diphosphono1,2-propanodicarboxylic acid, and hydromethylene diphosphonate, and PYP is used in the United States. In the absence of a light-chain abnormality, the 99m Tc-PYP scan is diagnostic of ATTR-CM if there is grade 2/3 cardiac uptake or an H/CL ratio of >1.5. In fact, the presence of grade 2/3 cardiac uptake in the absence of a monoclonal protein in serum or urine has a very high specificity and positive predictive value for ATTR-CM (7). SPECT is assessed in all positive scans to confirm that uptake represents myocardial retention of the tracer and not blood pool or rib uptake signal (12).

(из раздела Diagnosis of Cardiac Amyloidosis)