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Aug 4, 2023 13:56
9 mos ago
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English term
Biochemical CDK2 Caliper IC50
English to Russian
Medical
Biology (-tech,-chem,micro-)
In some embodiments, the present disclosureprovides a compound in Table 1, above, wherein the compound is denoted as having a Biochemical CDK2 Caliper IC50 of “A”. In some embodiments, the present disclosure provides a compound in Table 1, above, wherein the compound is denoted as having a Biochemical CDK2 Caliper IC50 of “A” or “B”. In some embodiments, the present disclosure provides a compound in Table 1, above, wherein the compound is denoted as having a Biochemical CDK2 Caliper IC50 of “A” or “B” or “C”
Reference comments
2 hrs
Reference:
comment
I am unable to find your phrase on any site, only:
ARTS-021 is a Potent and Selective CDK2 Inhibitor That ...
Allorion Therapeutics
https://alloriontx.com › ARTS021_AACR2022
PDF
by J Liang — Enzymatic assay: ****Caliper Assay***; ATP concentration used at 1mM; CDK1, CDK2, CDK4, CDK6, CDK7 and CDK9 are in complex ... CDK4/6 cellular activity(IC50 nM).
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Note added at 2 heures (2023-08-04 16:44:46 GMT)
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Probe NVS-PAK1-1
the Chemical Probes Portal
https://www.chemicalprobes.org › nvs-pak1-1
Potency Assay: ****Caliper IC50 assay****. IC50 values were derived from % inhibition values at different compound concentrations by non-linear regression analysis.
ARTS-021 is a Potent and Selective CDK2 Inhibitor That ...
Allorion Therapeutics
https://alloriontx.com › ARTS021_AACR2022
by J Liang — Enzymatic assay: ****Caliper Assay***; ATP concentration used at 1mM; CDK1, CDK2, CDK4, CDK6, CDK7 and CDK9 are in complex ... CDK4/6 cellular activity(IC50 nM).
--------------------------------------------------
Note added at 2 heures (2023-08-04 16:44:46 GMT)
--------------------------------------------------
Probe NVS-PAK1-1
the Chemical Probes Portal
https://www.chemicalprobes.org › nvs-pak1-1
Potency Assay: ****Caliper IC50 assay****. IC50 values were derived from % inhibition values at different compound concentrations by non-linear regression analysis.
8 hrs
Reference:
https://patents.google.com/patent/RU2589696C2/ru
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Note added at 8 hrs (2023-08-04 22:13:53 GMT)
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Ошибка, надо
https://patents.google.com/patent/RU2589696C2/ru
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Note added at 8 hrs (2023-08-04 22:22:11 GMT)
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http://www.eapatis.com/Data/EATXT/eapo2016/PDF/023821.pdf
Для измерения ингибирования...
Планшет считывали на приборе Caliper LC 3000...
Процентное
превращение наносили на график против концентрации ингибитора для получения сигмоидальной кривой
доза-эффект, из которой вычисляли значение IC50
--------------------------------------------------
Note added at 8 hrs (2023-08-04 22:28:10 GMT)
--------------------------------------------------
https://patents.google.com/patent/RU2743343C2/ru
Значение IC50 определяли с помощью биохимического анализа активности киназы ATM
--------------------------------------------------
Note added at 8 hrs (2023-08-04 22:13:53 GMT)
--------------------------------------------------
Ошибка, надо
https://patents.google.com/patent/RU2589696C2/ru
--------------------------------------------------
Note added at 8 hrs (2023-08-04 22:22:11 GMT)
--------------------------------------------------
http://www.eapatis.com/Data/EATXT/eapo2016/PDF/023821.pdf
Для измерения ингибирования...
Планшет считывали на приборе Caliper LC 3000...
Процентное
превращение наносили на график против концентрации ингибитора для получения сигмоидальной кривой
доза-эффект, из которой вычисляли значение IC50
--------------------------------------------------
Note added at 8 hrs (2023-08-04 22:28:10 GMT)
--------------------------------------------------
https://patents.google.com/patent/RU2743343C2/ru
Значение IC50 определяли с помощью биохимического анализа активности киназы ATM
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