English to Polish Science Mathematics & Statistics

However, the authors knowingly stratified the analysis based on the participants' gender, year of birth, month of birth, and clinic most often visited. This effectively reduced the variability of Thimerosal exposure within the strata to the point that it reduced the capability of the final analysis to find any but the “strongest” Thimerosal exposure-related outcome effects. The problems with such “overmatching” practices have been discussed in detail in peer-reviewed scientific literature and will be treated in greater detail in the forthcoming review of the CDC's Price et al. [26] paper.

As mentioned earlier, in case-control studies, the main methodological concern is the phenomenon called “overmatching.” This concern for overmatching in the Price et al. [26] study was voiced previously by DeSoto and Hitlan [32]. In their comprehensive analysis of overmatching errors specific to the Price paper, DeSoto and Hitlan [32] stated that “Matching cannot—or should not—be done in a way that artificially increases the chance that within[-] strata exposure is the same; this happens when a matching variable is a significant predictor of exposure and is called overmatching.”

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