drug survival

French translation: "survie du médicament" / taux de rétention du traitement

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:drug survival
French translation:"survie du médicament" / taux de rétention du traitement
Entered by: Daryo

06:16 Nov 15, 2017
English to French translations [PRO]
Medical - Medical (general)
English term or phrase: drug survival
Bonjour,

Je sais que ce terme a déjà été recherché mais je souhaitais avoir d'autres opinions sur le sujet.

Il s'agit d'un article sur le psoriasis :

Safety, efficacy, and drug survival of biologics for psoriasis

Ustekinumab was the biologic agent presenting with the longest drug survival.

Interchanging originator drugs for biosimilars did not have a significant impact on drug survival.

D'après ce que j'ai compris, "drug survival" signifie le temps passé sous traitement (du début à l'interruption). N'y a-t-il pas un autre terme consacré plutôt que "temps passé sous traitement" ?

Merci pour votre aide.

Suzy
SuzyKeller
France
Local time: 17:09
"survie du médicament" / taux de rétention du traitement
Explanation:

"... A recent review of the data from 19 clinical trials has shown that 5–29% of patients discontinue the anti-TNF-a agent within the 24–30-week treatment period.

Adherence to treatment (also referred to as ‘drug survival’) seems to be highest for etanercept followed by adalimumab and infliximab. Data for longer treatment durations are scarce but suggest an annual drop-out rate in the range 15–25% ..."
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2133.2011....

"Drug survival in rheumatoid arthritis

Department of Rheumatology and 1Department of Psychology (Physical Health and Rehabilitation), Cannock Chase Hospital, Brunswick Road, Cannock, WS11 2XY, UK

Accepted May 26, 2006.

... ‘Drug survival’ ***** measures the length of time a patient continues to take a particular drug *****: it is a well-recognized measure of drug effectiveness, which encompasses factors such as adverse drug reactions and side-effects, poor adherence, loss of efficacy and others. To measure drug survival, it is simply necessary to ask the patient when starting on a new medication to note the date they stop taking the medication regularly. Although drug survival has been examined in a variety of medical situations, it has not previously been extensively studied in RA.
...
Drug survival is cheap and easy to measure: understanding the factors that contribute to drug survival can only add to our understanding of compliance/adherence. In this case, if we assume that drug survival is a ‘good’ outcome, we need to target our counselling at those who are older/less anxious. Given that beliefs about medications do not appear to influence drug survival, these somewhat counter-intuitive and intriguing findings challenge our approach to promoting compliance/adherence/drug survival in our rheumatology patients.
http://rheumatology.oxfordjournals.org/content/45/9/1178.1.f...


A ce jour il existe très peu d'informations comparant le taux de rétention de ces traitements ("survie du médicament") et les causes de leur d'arrêt, en particulier ..."
http://www.rheumasearch.ch/ProjetsEnCours.html


--------------------------------------------------
Note added at 8 hrs (2017-11-15 14:53:30 GMT)
--------------------------------------------------

IOW how long the drug - NOT the patient will "survive" (i.e. how long the drug will keep being used by the patient) - until the patient gets bored of it, starts forgetting to take it, decides "it's no longer needed", has had enough of unpleasant sides effects etc ...

--------------------------------------------------
Note added at 1 day 2 mins (2017-11-16 06:19:14 GMT)
--------------------------------------------------

well explained:

Dermatologie. Happy drug survival : la clé pour assurer une bonne réponse clinique à long terme

La pratique quotidienne nous apprend quelque chose d’autre. Malgré l’existence d’outils d’évaluation et d’objectifs de traitement pour de nombreuses maladies importantes, le résultat à long terme dans la prise en charge de ces maladies dépend en grande partie d’une variable jusqu’ici sous-estimée, à savoir l’adhésion thérapeutique du patient.

https://www.revmed.ch/RMS/2016/RMS-N-500-501/Dermatologie.-H...

"survie du médicament" / "taux de rétention du traitement" two faces of the same coin one from the viewpoint of the drug (stays "alive" = keeps being used as opposed to "dead" = no one wants it) the other one from the viewpoint of the patient's behaviour.

You could make a parallel with a language [or a book] being dead or alive / [= "surviving"] as long as some people keep using it / reading it - "drug survival" is not exactly some made-up weird figure of speech plucked out of thin air !!!
Selected response from:

Daryo
United Kingdom
Local time: 16:09
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
5"survie du médicament" / taux de rétention du traitement
Daryo
4 -1survie des patients (ou des répondeurs) sous Ustekinumab
Drmanu49
3durée de réponse au traitement
orgogozo


Discussion entries: 2





  

Answers


2 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): -1
survie des patients (ou des répondeurs) sous Ustekinumab


Explanation:
Évolution des conditions d'initiation du traitement antirétroviral des ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722501/
de J Bashi - ‎2010 - ‎Cité 11 fois - ‎Autres articles
L'âge médian à la mise sous traitement était constant: 35 ans chez les femmes et ... doivent être développées pour améliorer la survie des patients sous TARV.

Ustekinumab dans la maladie Crohn réfractaire aux anti-TNF : une ...
www.fmcgastro.org/.../ustekinumab-dans-la-maladie-crohn-ref...
Les patients qui avaient reçu de l'Ustekinumab SC pour une maladie de Crohn active dans 20 ... Le critère de jugement principal était la survie sans échec du traitement, définie comme ... La durée médiane sous Ustekinumab était de 2,2 ans.

L'ustékinumab confirme son intérêt dans le traitement de la maladie ...
https://www.univadis.fr/.../l-ustekinumab-confirme-son-inter...
L'ustékinumab confirme son intérêt dans le traitement de la maladie de Crohn ... d'induction après une thérapie à visée curative radicale prolonge la survie ... Ainsi, 397 patients ayant obtenu une réponse sous ustekinumab ont été randomisés ...

Drmanu49
France
Local time: 17:09
Specializes in field
Native speaker of: Native in EnglishEnglish, Native in FrenchFrench
PRO pts in category: 5457
Notes to answerer
Asker: Je ne pense pas qu'il s'agisse de la survie des patients ici. Il n'y a aucun décès dans l'étude. Il s'agit


Peer comments on this answer (and responses from the answerer)
disagree  Daryo: that was the previously chosen nonsensical answer// a fine textbook example of a type of "cognitive bias" - obstinately refusing to see another use/meaning for "la survie" except the usual/most frequent one (not sure how that bias is called ...)
5 hrs
  -> survie sans échec du traitement
Login to enter a peer comment (or grade)

8 hrs   confidence: Answerer confidence 5/5
"survie du médicament" / taux de rétention du traitement


Explanation:

"... A recent review of the data from 19 clinical trials has shown that 5–29% of patients discontinue the anti-TNF-a agent within the 24–30-week treatment period.

Adherence to treatment (also referred to as ‘drug survival’) seems to be highest for etanercept followed by adalimumab and infliximab. Data for longer treatment durations are scarce but suggest an annual drop-out rate in the range 15–25% ..."
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2133.2011....

"Drug survival in rheumatoid arthritis

Department of Rheumatology and 1Department of Psychology (Physical Health and Rehabilitation), Cannock Chase Hospital, Brunswick Road, Cannock, WS11 2XY, UK

Accepted May 26, 2006.

... ‘Drug survival’ ***** measures the length of time a patient continues to take a particular drug *****: it is a well-recognized measure of drug effectiveness, which encompasses factors such as adverse drug reactions and side-effects, poor adherence, loss of efficacy and others. To measure drug survival, it is simply necessary to ask the patient when starting on a new medication to note the date they stop taking the medication regularly. Although drug survival has been examined in a variety of medical situations, it has not previously been extensively studied in RA.
...
Drug survival is cheap and easy to measure: understanding the factors that contribute to drug survival can only add to our understanding of compliance/adherence. In this case, if we assume that drug survival is a ‘good’ outcome, we need to target our counselling at those who are older/less anxious. Given that beliefs about medications do not appear to influence drug survival, these somewhat counter-intuitive and intriguing findings challenge our approach to promoting compliance/adherence/drug survival in our rheumatology patients.
http://rheumatology.oxfordjournals.org/content/45/9/1178.1.f...


A ce jour il existe très peu d'informations comparant le taux de rétention de ces traitements ("survie du médicament") et les causes de leur d'arrêt, en particulier ..."
http://www.rheumasearch.ch/ProjetsEnCours.html


--------------------------------------------------
Note added at 8 hrs (2017-11-15 14:53:30 GMT)
--------------------------------------------------

IOW how long the drug - NOT the patient will "survive" (i.e. how long the drug will keep being used by the patient) - until the patient gets bored of it, starts forgetting to take it, decides "it's no longer needed", has had enough of unpleasant sides effects etc ...

--------------------------------------------------
Note added at 1 day 2 mins (2017-11-16 06:19:14 GMT)
--------------------------------------------------

well explained:

Dermatologie. Happy drug survival : la clé pour assurer une bonne réponse clinique à long terme

La pratique quotidienne nous apprend quelque chose d’autre. Malgré l’existence d’outils d’évaluation et d’objectifs de traitement pour de nombreuses maladies importantes, le résultat à long terme dans la prise en charge de ces maladies dépend en grande partie d’une variable jusqu’ici sous-estimée, à savoir l’adhésion thérapeutique du patient.

https://www.revmed.ch/RMS/2016/RMS-N-500-501/Dermatologie.-H...

"survie du médicament" / "taux de rétention du traitement" two faces of the same coin one from the viewpoint of the drug (stays "alive" = keeps being used as opposed to "dead" = no one wants it) the other one from the viewpoint of the patient's behaviour.

You could make a parallel with a language [or a book] being dead or alive / [= "surviving"] as long as some people keep using it / reading it - "drug survival" is not exactly some made-up weird figure of speech plucked out of thin air !!!


Daryo
United Kingdom
Local time: 16:09
Works in field
Native speaker of: Native in SerbianSerbian, Native in FrenchFrench
PRO pts in category: 67
Login to enter a peer comment (or grade)

1 day 11 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
durée de réponse au traitement


Explanation:
en l'absence d'issue fatale dans le psoriasis c'est la "survie" du traitement qui est évoquée plutôt que la survie du patient

orgogozo
France
Local time: 17:09
Specializes in field
Native speaker of: Native in FrenchFrench
PRO pts in category: 178

Peer comments on this answer (and responses from the answerer)
neutral  Daryo: durée d'adhésion au traitement // si le traitement s'avère inefficace, il n'y aura aucune "réponse au traitement" malgré "l'adhésion thérapeutique".
10 hrs
  -> le traitement cesse d'être efficace au bout d'un certaine temps. Dixit une demarto de ma connaissance.
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